switching from semaglutide to tirzepatide results : r/tirzepatidecompound 🚨 Trying to choose between

First, the lower levels of active incretin compared to healthy subjects due to the increased degradation by dipeptidyl peptidase-4 and reduced incretin production in patients with NAFLD may explain the beneficial effect of GLP-1RA in NAFLD treatment [44]

Unfortunately, like other GLP1R agonists, retatrutide also produced significant GI side effects in a large proportion of participants (35% in the 36 week study and 45% in the 48 week study at the 12 mg dose) (Jastreboff et al., 2023

The mice received daily subcutaneous doses with tirzepatide (3 nmol/kg) or vehicle (40 nM Tris buffer) for 6 days

These two drugs work through different systems

This divergence in functionality between SST and the anorexigenic effects of GLP-1RAs would appear to exclude the involvement of SST in the regulation of appetite by semaglutide